My instincts would be that publishers might want to play it safe and go for the equivalent of literary comfort food - books that are easy to consume in large amounts but ultimately not very good for the body and soul...
If this is a natural reflection of people's buying habits, then the smaller, more selective publishers may well find times hard.
There was another thread somewhere on this site with a link to an external discussion/blog on this subject but I can't find it now.
S