Hi, Debbie, and welcome to WriteWords
As Dee says, it is very difficult to get an autobiography published unless you are famous, although it's not impossible. I love autobiographies, and there's a stack of them beside me, including the vet James Herriot; the Yorkshire schools inspector Gervase Phinn; Deric Longden; Joan Kent; the Irish poet Thomas Walsh; another irishman Bryan Gallagher... several of them initally wrote for Radio 4, eg, R4's Home Truths, and built up an avid following before expanding their collection of anecdotes into an autobiography. These days one can 'get it out there' via blogging which has led to book offers for some avidly followed bloggers.
One thing to bear in mind is minimum manuscript length is 80,000 words, so I would add an extra 10K to yours to give it a better chance with Agents and publishers.
As for self-publishing, if you go that route, then I would recommend doing it via the Lulu Print On Demand (POD) publishing site. Don't bother with ISBN numbers or trying to get it into Amazon or the bookshops, just do it for friends and family, and buy a few copies yourself to hand round at Christmas.
- NaomiM
<Added>I have to add, though, that 'issues' don't tend to sell autogiographies (unless it falls into the 'misery memoir' genre) but rather an interesting line of work full of funny and poignant anecdotes and an historical record of the times, is what publishers seem to prefer.